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US wholesale viagra cheaper price states cities and details introduction.
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Viagra effects and its development history
Viagra Sildenafil,developed by the Pfizer pharmaceutical company, was first used to treat cardiovascular disease as a 5-phosphodiesterase inhibitor to enter clinical studies. The researchers hope that sildenafil by release the bioactive substance nitric oxide can make cardiovascular smooth muscle relaxation, to achieve the object of dilation of blood vessels, cardiovascular disease remission.
However, clinical studies have shown that the effect of sildenafil on cardiovascular can not meet the researchers expectation, as a cardiovascular drug,sildenafil performance was disappointing,can not grow to be a successful treatment.
April 1991, clinical studies of sildenafil formally failed, but a side effect reported by subjects attracted the attention of researchers. The researchers found that, after the treatment had brought the reagent are reluctant to hand over the rest of the drugs. Under tracing, we found that the drug has improved the patient’s sex life.
After license by Pfizer high-level, researchers carried out research of sildenafil effect on corpus, and marketing authorization the US Federal Food and Drug Administration on March 27, 1998, became a reputation product of Pfizer.
In 1998, the United States and European food and drug regulatory authorities (FDA and EFSA) approved sildenafil (Viagra) listed to treat ED, its magical efficient arouse worldwide sensation. Sildenafil results of clinical studies published in leading medical journal “New England Journal of Medicine”.
In 1999, “Viagra” is the term included in the Oxford English Dictionary, at the same time, clinical research confirmed its cardiovascular safety.
In 2000, the study further confirmed the safety of sildenafil in blood pressure, as well as safety in combination with antihypertensive drugs. Articles published in the “Journal of Hypertension”;
In November 2000, Viagra won the French Prix Galien award
2001, Viagra has been approved in the global market more than 100 countries, an average of 9 pills prescriptions per second.
In 2002, human clinical studies confirm sildenafil had no effect on sperm function, the article published in the “British Journal of Clinical Pharmacology”;
In 2003, 120 controlled studies confirmed that sildenafil does not increase risk of MI / cardiovascular death, the article published in “International Journal of Clinical Practice”;
In 2004, studies confirm that sildenafil by improving erections, improve the patient’s self-confidence, self-esteem, relationship with a sexual partner, and overall quality of life (SEAR and QoL)
2005, Viagra has more than 750,000 prescriptions, over 23 million men use
In 2006, the study further confirmed that Viagra help men achieve erection hardness level 4 (optimal erection hardness), article published in Journal of Sexual Medicine
In 2007, the four-year long-term studies confirm Viagra’s long-term safety and efficacy, the article published in Therapeutics and Clinical Risk Management
In 2008, researchers confirmed that erection hardness is important treatment expectation for ED patients, SCORED study published in International Journal of Impotence Research
In 2009, the ultrasound study confirmed, Viagra 100mg therapy significantly improved blood flow in the penis, the article published in Journal of Sexual Medicine
In 2010, the meta-analysis to further verify its safety (67 double-blind, placebo-controlled study), the article published in International Journal of Clinical Practice
2013, Viagra new packaging on the market
2015, sildenafil in Pubmed database contained literature has more than 5800, there are more than 780 million men use Viagra
Viagra Experience Survey
A 2618 patients were enrolled for up to 2–3 years open-label studies (patient has completed preliminary studies continue to participate in one-year extension studies) show that:
95.3% of patients believe that in the long course of treatment, Viagra has always been able to increase its sexual potency (the principal investigator is for people in the United States New York,Washington, California, Florida, Georgia,New jersey, New mexico, Pennsylvania, Maryland etc. want to buy wholesale best original viagra pills,contact : email@example.com )
Viagra common adverse reactions were headache, flushing, indigestion, usually mild to moderate and short duration
Compared with placebo, taking Viagra without increasing the incidence of serious adverse events in patients
Patients taking any form of nitrates are Viagra absolute contraindications
Before sex about one hour oral taking,under sexual stimulation natural erection
82% of patients believe that after taking viagra they are more intimate with your spouse (main survey area is the United States: Alabama, Alaska, Indiana, Connecticut, Kentucky, New york, Nevada, Wyoming, Texas, Mississippi, New jersey, Ohio, Rhode island, Massachusetts, New hampshire, Minnesota, Pennsylvania, North carolina, Michigan)
Some young people of childbearing age, due to the pressure of life, work and the fertility other aspects, can cause ovulation ED, that is, during the planned pregnancy, erectile dysfunction,when can by using Viagra successfully completed childbearing tasks.in many clinical experiments have not found Viagra has affect on sperm.
86% of patients improved quality of sex life (the main survey area of the United States: Kansas, Maine, Missouri, South carolina, Virginia, Washington, Oklahoma, Louisiana, Tennessee, West virginia, Montana, Arizona, California, Hawaii, Idaho)
90% of patients become more confident on the sex life (the main survey area of the United States: Colorado, Florida, Maryland, Nebraska, Utah, North dakota, South dakota, New mexico, Wisconsin, Oregon, Vermont, Iowa, Georgia, Illinois, Delaware , Arkansas)
ED is a disease associated with many chronic diseases,
Diagnosis of ED, can help doctors earlier found patients with certain underlying chronic disease
Undeniably,Viagra is the world’s best and most popular effective ED PE products, made a revolution contribution to the global men.
Taking Viagra Precautions
1: Viagra must not mix with treat heart disease nitrates (such as nitroglycerin, isosorbide dinitrate), or may significantly lower blood pressure, leading to life-threatening;
drinking can seriously reduce the effectiveness of Viagra erection, so should not overdose drinking. In addition, it is best not to immediately take just showered.
2: Before using the “Viagra” drugs, first we need to know two things:
First, if he has several more serious illness; second, whether the user is able to afford the sexual life required tremendous energy and stamina expenditures.
If you suffer from heart disease, stroke, retinitis pigmentosa, kidney disease, liver disease, blood disease, penile deformity, before taking sure to consult an expert. People who are taking nitroglycerin, isosorbide dinitrate and other nitrates drugs can not arbitrarily take Viagra. Finally, poor physical,poor heart affordability people can not use.
3: Taking Viagra itself does not cause or increase the libido, but its role in the event of sexual impulses, to help erectile dysfunction patients restore normal erectile function. Simply put, it is to help restore a person’s normal sexual function, so that patients in the natural erection when sexual impulses.
Studies have evidence that Viagra can effectively prolong ejaculation latency, improve erectile hardness, long-term intermittent or continuous take, it is possible to improve penile endothelial function, and further improve the quality of erections. Usually poor erectile function people, can try to use Viagra to improve erection, but people who has good erection do not abuse.
4: Viagra should not drink the same time, not to say that can not drink, problem is drinking can seriously reduce the effectiveness of Viagra erection.
5: cimetidine, erythromycin, ketoconazole, itraconazole and Mibeilei and other CYP 3A4 inhibitors can reduce the metabolism Viagra, may increase the Viagra plasma concentration. Rifampicin is the most clinically CYP 3A subfamily enzyme inducer, can enhance the activity of CYP 3A4, reduce the effects of Viagra
Viagra has been on the market is not a stranger, large pharmacies and online is available,or can buy at regular pharmacies or hospital.
Price: original Viagra in the US retail price is $ 8-12 per one pill, and requires a prescription to buy (but in many countries do not need a prescription to buy Viagra, as long as an adult,it can not sure why).
In the United States,there are some large population states the retail price will be 10-20% cheaper than other places such as: Mississippi, New jersey, New york, Washington, Pennsylvania, Florida, Georgia, New mexico, California.
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Where to buy Viagra in US
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15 Iowa – IA :
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